New PDF release: Actin-based Motility: Cellular, Molecular and Physical

By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)

ISBN-10: 9048193001

ISBN-13: 9789048193004

This e-book offers the mobile, molecular and actual points of strength and flow by way of the self-assembly of actin, the most considerable proteins present in cells, into cytoskeletal filaments. « Actin-based motile approaches » are accountable for a wide number of motile actions resembling chemotactic locomotion, embryonic and metastatic cellphone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic techniques together with, axis patterning in early embryos, axonal progress in mind improvement, and the immune reaction and synaptic plasticity procedures on the foundation of studying and reminiscence. The e-book describes how the lately undertaken multidisciplinary and multiscale ways have explored the molecular and actual mechanisms on the starting place of strength and stream produced via actin self-assembly. the selected subject matters convey how advances were made within the box of cellphone motility because of the growth in reside telephone imaging, mild microscopy, more desirable answer within the constitution of enormous protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the improvement of nanotechnologies permitting us to degree forces within the diversity of pico- to nano-newtons produced by way of actin assemblies.

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Additional info for Actin-based Motility: Cellular, Molecular and Physical Aspects

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Jacob, M. P. V. Small. 2010. Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol. 12:429–35. , J. Condeelis, and M. Glogauer. 2009. A common cofilin activity cycle in invasive tumor cells and inflammatory cells. J Cell Sci. 122:305–11. R. Prochnow, E. K. Ramasamy, P. H. Arnold. 2007. Arp3 is required during preimplantation development of the mouse embryo. FEBS Lett. 581: 5691–97. , S. Kojima, Y. Aratyn, O. Danciu, T. G. Borisy. 2006. Role of fascin in filopodial protrusion.

2001. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol. 11:1645–55. , G. Craig, V. Dominguez, and B. Baum. 2003. Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr Biol. 13:1867–75. A. W. Dent, J. D. Leslie, J. M. Mebane, U. M. A. T. Bronson, S. Mori, R. B. Gertler. 2007. Ena/VASP is required for neuritogenesis in the developing cortex. Neuron. 56:441–55. , and K. Rottner. 2008.

Frank, M. Reinhard, E. D. Carl, U. B. Gertler, J. Wehland, and T. Chakraborty. 1997. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J. 16:5433–44. , and A. Hall. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:53–62. , N. Tomasevic, A. W. Pierce, Z.

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Actin-based Motility: Cellular, Molecular and Physical Aspects by J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)


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